Toxic effects of ozone on murine L929 fibroblasts. Damage to DNA
- 1 October 1987
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 247 (1) , 69-72
- https://doi.org/10.1042/bj2470069
Abstract
Damage to DNA caused by exposure of L929 fibroblasts to ozone was reflected by the generation of strand breaks, DNA inter-strand cross-links and DNA-protein cross-links. Addition of propan-2-ol, a hydroxyl radical scavenger, did not affect the formation of strand breaks. In model experiments it appeared that both purines and pyrimidines were involved in DNA inter-strand and DNA-protein cross-links.Keywords
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