EFFECT OF BCG CELL-WALL SKELETON ON METASTASIS OF SYNGENEIC TUMOR IN RATS, WITH SPECIAL REFERENCE TO LYMPHOCYTE TRAPPING

  • 1 January 1978
    • journal article
    • research article
    • Vol. 69  (3) , 311-315
Abstract
Oil-attached BCG cell wall skeleton (BCG-CWS) induced lymphocyte trapping in the draining node in rats. It also acts as a potent adjuvant for lymphocyte trapping when injected into a growing syngeneic transplantable fibrosarcoma. Treatment with repeated intratumor injections into the primary tumor resulted in suppression of tumor growth in primary and metastatic sites. Even when the primary tumor escaped regression, the inhibitory effect on metastatic spread was attained by the therapy. The contribution of BCG-CWS to suppression of metastases especially in the draining node was discussed from the point of lymphocyte trapping in the draining node.