The Effect of Mercaptoethylamine on Survival of Mice Irradiated with Cobalt 60

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Abstract
The action of [beta]-mercaptoethylamine (Becaptan) against early radiation death was studied in mice irradiated with Co60. A total of 485 C57BL/6 mice of both sexes, aged 38 [plus or minus] 3 days, was assigned to treatment groups receiving 4 different total doses according to a graded sequence, in 2 fractions, at a 5-day interval. Data were analyzed by the probit method. In the group treated with Becaptan, the 30-day LD50 value was increased from 416 to 700 r. The degree of protection afforded was statistically significant. The death pattern was bimodal, and two components were identified. An analysis of the data by two simultaneous probit regression curves is presented. It is assumed that the killing action of gamma-rays is statistically similar to the joint independent action of two components. The mechanism of action of Bercaptan is discussed accordingly. The degree of protection afforded by Becaptan against the first mode was moderate at any dose level of irradiation. The protection against late marrow death, however, was highly significant. At lower dosages this component practically disappeared.