Effect of Injection of Rat Bone Marrow on Recticular Tissues of Mice Exposed to X Radiation in the Midlethal Dose Range2

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Abstract
The 30-day mortality in 198 C3H X 101F1 hybrid mice exposed to 710 r of X-radiation was 30%. Forty-one irradiated mice given rat bone marrow intravenously showed 100% mortality in 16 days with bone marrow aplasia as well as hemorrhage, infection, and anemia. Fifty mice given 710 r and isologous bone marrow had no deaths in the 30-day period. Twenty mice in each of the following groups were killed and necropsied during a 30-day period. The groups were 710 r plus rat bone marrow, 710 r only, 710 r plus isologous bone marrow, and unirradiated mice plus rat bone marrow. Irradiated mice receiving isologous or heterologous bone marrow showed recovery of bone marrow and splenic red pulp in 5 days. Untreated irradiated mice recovered in 2 weeks. Non-irradiated rat marrow-injected mice showed no changes. Complete secondary destruction of the bone marrow and splenic red pulp was seen 6-8 days after exposure in the irradiated mice given rat bone marrow and led to the death through hemorrhage, infection, and anemia. To test this hypothesis, 20 mice were exposed to 710 r and given rat bone marrow. Six days later, each received a massive dose of isologous bone marrow intravenously. Four mice died in 15 days and 16 recovered.