CONCORDANT SEGREGATION OF THE EXPRESSION OF SV40 T ANTIGEN AND HUMAN CHROMOSOME 7 IN MOUSE-HUMAN HYBRID SUBCLONES
Open Access
- 1 May 1974
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 139 (5) , 1350-1353
- https://doi.org/10.1084/jem.139.5.1350
Abstract
Subcloning of Simian virus 40 (SV40) T antigen-positive mouse-human hybrids, derived from the fusion of mouse cells deficient in thymidine kinase with SV40-transformed Lesch Nyhan fibroblasts, resulted in their segregation into T antigen-positive and negative subclones. Positive correlation between the presence of human chromosome 7 and the expression of SV40 T antigen was established in the subclones examined. These results negate the possibility of a transfer of the SV40 genome to a mouse chromosome.Keywords
This publication has 5 references indexed in Scilit:
- Preferential retention of the human chromosome C-7 in human-(thymidine kinase deficient) mouse hybrid cellsExperimental Cell Research, 1973
- Assignment of the T-Antigen Gene of Simian Virus 40 to Human Chromosome C-7Proceedings of the National Academy of Sciences, 1973
- Human Regulatory Gene for Inducible Tyrosine Aminotransferase in Rat-Human HybridsProceedings of the National Academy of Sciences, 1973
- Genetic Analysis with Human—Mouse Somatic Cell HybridsNature, 1969
- Detection of Adenovirus Type 12 Neoantigen(s) in a Continuous Human Amnion Cell Line (FL) by Immunofluorescence.Experimental Biology and Medicine, 1965