Pemoline‐induced chorea

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Abstract
Pemoline mesylate is a central stimulant used to treat children with minimal brain dysfunction. Acute chorea in a child followed accidental ingestion of pemoline mesylate [Cylert]. In guinea pigs, in an experimental model of chorea, chronic administration of premoline induced behavioral supersensitivity to other dopaminergic agonists. Pemoline is similar to both d-amphetamine and methylphenidate in altering central dopaminergic sensitivity, and may cause chorea by similar mechanisms. Chronic pemoline therapy may offer no significant advantage over therapy with other indirect dopamine agonists.