Occupational argyria; light and electron microscopic studies and X-ray microanalysis

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Abstract
Microscopic studies were performed on skin biopsies from 5 patients with occupational argyria. Small brown-black granules were present in the dermis on light microscopy and were intensely refractile with dark-field illumination. EM showed that the granules were electron dense, round or oval in shape and varied in size from 30-100 nm. They were most numerous in relation to the basal lamina of the eccrine sweat glands but were also present in relation to the basal lamina of the epidermis and dermal elastic fibers. X-ray microanalysis confirmed that many granules contained Ag and S. Se, Hg, Ti and Fe were also identified and it was probable that these elements were deposited in the skin as a result of occupational exposure.

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