Abstract
In 3 [human] cases of generalized argyria the degree of slate-gray cutaneous discoloration varied from barely perceptible to pronounced. Deposition of As-containing granules in and around cutaneous adnexal structures was best seen with darkfield microscopy. Histochemical studies suggested that the granules consisted of silver sulfide. Indiscriminate use of currently available Ag-containing medications can result in generalized argyria.

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