EFFECTS OF PROSTAGLANDINS-A2, PROSTAGLANDINS-E2 AND PROSTAGLANDINS-F2ALPHA ON ERYTHROPOIETIN PRODUCTION

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 198  (2) , 489-496
Abstract
The erythropoietic effects of the renal prostaglandins [PG] were investigated in exhypoxic polycythemic mice and in isolated perfused dog kidneys. PG A2 and E2 in a dose range of 100-800 .mu.g/kg body weight produced a dose-related increase in radioactive Fe-incorporation in red cells. PG F2.alpha., was devoid of an erythropoietic effect in polycythemic mice. In that PGE2 is the principal renal PG, PGE2 (0.5 .mu.g/min) or saline was infused into isolated perfused dog kidneys that had been programmed by prior exposure to hypoxia (0.42 atm) for 4 h. PGE2-infused kidneys during 5 h of perfusion with blood from nonhypoxic donor dogs produced significant increases in perfusate titers of erythropoietin when compared with that of saline infusion controls at the same time intervals. These data suggest an involvement of the renal PGE2 in erythropoietin production by the kidney.

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