Studies on peptides. CXXXIII. Synthesis and biological activity of galanin, a novel porcine intestinal polypeptide.
- 1 January 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (2) , 528-539
- https://doi.org/10.1248/cpb.34.528
Abstract
A new porcine gastrointestinal 29-residue peptide, galanin, was synthesized in a satisfactory yield by assembling seven peptide fragments followed by deprotection with 1 M trifluoromethane-sulfonic acid-thioanisole in trifluoroacetic acid. Nin-Mesitylenesulfonyltryptophan was employed to suppress indole alkylation during Na-deprotection. β-Cycloheptylaspartate was employed to suppress base-catalyzed succinimide formation. The synthetic peptide exhibited a powerful contractile activity on rat ileum, but not on guinea pig ileum and caused sustained hyperglycemia in dogs.Keywords
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