Serum Proteins, Lipoproteins and Glycoproteins. II. Muscular Dystrophy and Related Diseases in Patients.

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Abstract
Summary 1. Serum proteins, lipoproteins and glycoproteins were studied primarily in pseudohypertrophic muscular dystrophy (PMD), myositis, myotonia dystrophia and amyotrophic lateral sclerosis, and in scoliosis and Perthes disease with occasional secondary muscular changes. 2. Moving boundary electrophoretic patterns revealed significant, although not specific, increase of α2-globulin in nearly all muscle diseases. This increase seemed to be related to a high level of sialic acid, particularly in PMD. 3. Distribution of lipoproteins in paper electrophoretic patterns and concentrations of cholesterol and phospholipids did not show the pronounced changes previously found in muscular dystrophy of vit. E-deficiency in rabbits. 4. In contrast to this experimental myopathy and many other wasting diseases, human muscle diseases were not accompanied by significant increase of protein-bound carbohydrates other than that of sialic acid in PMD.

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