Mutations in a signalling pathway
- 10 August 2005
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 436 (7052) , 792
- https://doi.org/10.1038/436792a
Abstract
Protein kinases are enzymes that are important for controlling cellular growth and invasion1, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.Keywords
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