Search for differences among t haplotypes in distorter and responder genes

Publisher Website
Google Scholar
Abstract
Summary Transmission ratio distortion due to the mouse t complex is thought to be due to harmful effects of trans-acting distorter genes acting on a responder, with the t complex form of the responder being relatively resistant to this harmful action of the distorters. Previous work had indicated that naturally occurring t haplotypes differed in their responders or in distorters lying near the responder, with the result that animals doubly heterozygous for two responder-carrying haplotypes transmitted these haplotypes unequally. In the present work t haplotypes could be divided into three types on the basis of their transmission when doubly heterozygous with the responder-carrying partial haplotype tlowH . The majority, t 0, t 6, tw1 , tw2 and tw73 , were transmitted equally with tlowH , a second group, including t w5 and two haplotypes derived from it, were transmitted less frequently than tlowH , and the single member of a third group, t32 , was transmitted in excess of tlowH This last result suggests that the underlying differences are in the responder itself, rather than in the distorters. Search for differences among t haplotypes in distorters produced some equivocal results possibly resulting from effects of genetic background. In particular, results of others suggesting presence of a fourth distorter, Tcd-4, were not confirmed.