Positron emission tomography and histopathology in Pick's disease

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Abstract
PET using 18F-2-fluoro-2-deoxyglucose was carried out on a case of Pick9s disease established by necropsy. A sharply decreased cortical metabolic rate for glucose was obtained in specific gyri, especially in the frontal lobes, where there was extensive gliosis and neuronal loss. More moderate decreases were found in areas with numerous Pick bodies and inflated neurons but less gliosis. The PET pattern was sufficiently distinctive to suggest that it might be possible to distinguish Pick9s from Alzheimer9s disease premortem.