THE EFFECT OF lα-HYDROXYVITAMIN D3IN PRE-DIALYSIS RENAL BONE DISEASE
- 1 December 1977
- journal article
- Published by Wiley in Clinical Endocrinology
- Vol. 7 (s1) , 109s-116s
- https://doi.org/10.1111/j.1365-2265.1977.tb03370.x
Abstract
Assessment of 18 azotaemic patients treated with long-term 1alpha-hydroxyvitamin D3 (1alpha-OHD3) confirms the generally favourable effect of this analogue of 1,25-dihydroxyvitamin D3 in azotaemic osteodystrophy. Growing children with radiological rickets respond very well as do adults showing mild hyperparathyroidism with or without osteomalacia. However, patients with severe 'pure' hyperparathyroidism and features of autonomy do not respond well and in such patients 1alpha-OHD3 alone should be avoided. Phosphate restriction and occasionally a sub-total parathyroidectomy may be indicated in these patients.Keywords
This publication has 7 references indexed in Scilit:
- 1,25-dihydroxycholecalciferol in renal osteodystrophy. Epiphysiolysis--anticonvulsant therapy.Archives of Disease in Childhood, 1977
- Rate of reversal of hypercalcaemia and hypercalciuria induced by vitamin D and its 1alpha-hydroxylated derivatives.BMJ, 1977
- VITAMIN-D DEFICIENCY IN THE OSTEOMALACIA OF CHRONIC RENAL FAILUREThe Lancet, 1976
- 1-Alphahydroxycholecalciferol in Chronic Renal FailureAnnals of Internal Medicine, 1976
- 1α-Hydroxycholecalciferol. Long-Term Treatment of Patients with Uraemic OsteodystrophyNephron, 1976
- 1-alpha-hydroxyvitamin D3 in chronic renal failure. A potent analogue of the kidney hormone, 1,25-dihydroxycholecalciferolPublished by American Medical Association (AMA) ,1975
- Azotaemic renal osteodystrophy: a quantitative study on iliac boneJournal of Clinical Pathology, 1973