Improvement of Aqueous Solubility and Dissolution Kinetics of Canrenone by Solid Dispersion in Sucroester

Publisher Website
Google Scholar
Abstract
Sucroester 7 (sucrose di-stearate), by melting and rapid cooling, gives a product with a glassy appearance that corresponds to a low physical stability state or a high solubility power. This property, added to its surfactive characteristics, enables considerable improvement not only in aqueous solubility, but, to a greater degree, in the dissolution kinetics of canrenone. This result should lead to a reduction in the long lag time observed after oral administration before the diuretic effect of the product.