Kelletinin I and kelletinin A from the marine molluscBuccinulum corneum are inhibitors of eukaryotic DNA polymeraseα
- 1 January 1991
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 47 (1) , 64-66
- https://doi.org/10.1007/bf02041254
Abstract
The inhibitory effect of esters of p-hydroxybenzoic acid (kelletinins I and A), extracted from the marine gastropodBuccinulum corneum, have been tested on eukaryotic and prokaryotic enzymes of DNA metabolism such as DNA polymerasesα and β, DNA polymerase I, Exo III, pancreatic DNAse I, micrococcal DNAse andE. coli RNA polymerase. Kelletinin I and kelletinin A inhibit preferentially DNA polymeraseα. The inhibitory effect of kelletinin I involves the hydroxyl group of p-hydroxybenzoic acid.Keywords
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