Eccrine adenocarcinoma. A clinicopathologic study of 35 cases

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Abstract
A clinicopathologic study was made of 35 patients with primary eccrine adenocarcinoma diagnosed in the past 20 yr from among 450,000 consecutive skin biopsy specimens. Histologically, 4 distinct variants were identified: eccrine porocarcinoma (18 cases), syringoid eccrine carcinoma (12 cases), mucinous eccrine carcinoma (3 cases) and clear cell eccrine carcinoma (2 cases). Overall, eccrine adenocarcinomas are destructive lesions with a tendency to local recurrence. The syringoid histologic variant appears to be well differentiated and may have a benign clinical course; the lesion remained localized to the skin in all 12 cases. Regional lymphatic and distant metastasis occurred in 2 patients with eccrine porocarcinoma.