The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games
Top Cited Papers
Open Access
- 10 April 2005
- journal article
- review article
- Published by Wiley in Immunology
- Vol. 115 (1) , 1-20
- https://doi.org/10.1111/j.1365-2567.2005.02143.x
Abstract
Summary: The members of the tumour necrosis factor (TNF)/tumour necrosis factor receptor (TNFR) superfamily are critically involved in the maintenance of homeostasis of the immune system. The biological functions of this system encompass beneficial and protective effects in inflammation and host defence as well as a crucial role in organogenesis. At the same time, members of this superfamily are responsible for host damaging effects in sepsis, cachexia, and autoimmune diseases. This review summarizes recent progress in the immunbiology of the TNF/TNFR superfamily focusing on results obtained from animal studies using gene targeted mice. The different modes of signalling pathways affecting cell proliferation, survival, differentiation, apoptosis, and immune organ development as well as host defence are reviewed. Molecular and cellular mechanisms that demonstrate a therapeutic potential by targeting individual receptors or ligands for the treatment of chronic inflammatory or autoimmune diseases are discussed.Keywords
This publication has 248 references indexed in Scilit:
- Lymphotoxin‐β receptor mediates NEMO‐independent NF‐κB activationFEBS Letters, 2002
- Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseasesArthritis & Rheumatism, 2001
- TNF? and the TNF receptor superfamily: Structure-function relationship(s)Microscopy Research and Technique, 2000
- An Essential Role for Ectodomain Shedding in Mammalian DevelopmentScience, 1998
- Characterization of the Intracellular Domain of Receptor Activator of NF-κB (RANK)Journal of Biological Chemistry, 1998
- A Role for Tumor Necrosis Factor Receptor Type 1 in Gut-associated Lymphoid Tissue Development: Genetic Evidence of Synergism with Lymphotoxin βThe Journal of Experimental Medicine, 1998
- A central role of CD40 ligand in the regulation of CD4+ T-cell responsesImmunology Today, 1996
- Double Negative (CD4−CD8−αβ+) T Cells Which Promote Tolerance Induction and Regulate AutoimmunityImmunological Reviews, 1996
- Collagen-Induced Arthritis in Mice: Synergistic Effect of E. Coli Lipopolysaccharide Bypasses Epitope Specificity in the Induction of Arthritis with Monoclonal Antibodies to Type II CollagenAutoimmunity, 1995
- Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in LymphotoxinScience, 1994