CHROMOSOMAL-ABNORMALITIES ASSOCIATED WITH INFERTILITY

  • 1 January 1980
    • journal article
    • research article
    • Vol. 55  (4) , 469-475
Abstract
From 515 subfertile couples and 119 women with amenorrhea, 38 patients were karyotyped because of specific signs and symptoms suggestive of chromosomal abnormality. The indications for karyotyping included primary amenorrhea, secondary amenorrhea with gonadal failure before 35 yr of age, stature of < 147.5 cm, azoospermia with eunuchoidism, and personal or family history of > 2 spontaneous abortions or > 2 severely abnormal children. Patients [19] from the same subfertile population were selected randomly for karyotyping to serve as controls. Using banding techniques, chromosomal abnormalities were found in 18 of 38 specifically selected individuals, whereas no abnormality was found among those randomly selected. Three of the 18 patients had chromosomal abnormalities not previously described; their karyotypes were 46,XY/48,XY,+8,+21; 46,X,inv dup(Xq)(q26 .fwdarw. q21); and 46,XY, t(9;20)(q22;q12).