PROLIFERATIVE T-CELL RESPONSE TO HERPES-SIMPLEX VIRUS (HSV) ANTIGEN IS RESTRICTED BY SELF HLA-D
- 1 January 1980
- journal article
- research article
- Vol. 39 (3) , 668-675
Abstract
T [thymus-derived] cells from sensitized individuals react with a proliferative response to herpes simplex virus antigen (HSV-Ag) in vitro when Ag is presented together with autologous macrophages (M.vphi.). This T-M.vphi. cooperation is restricted by self HLA-D/DR molecules of the sensitized T cell donor. The lack of cooperation between T cells and HLA-D/DR disparate macrophages is due neither to suppression nor to generation of cytotoxic T cells in the allogeneic mixture.This publication has 8 references indexed in Scilit:
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