Multistep deprotection for peptide chemistry
- 1 August 1993
- journal article
- review article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 42 (2) , 97-117
- https://doi.org/10.1111/j.1399-3011.1993.tb00486.x
Abstract
This review article focuses on some concepts which make use of special classes of protecting groups (protected protecting groups) in peptide synthesis. Terms such as gradative deprotection, dual deprotection, two-step deprotection, safety-catch protection and multidetachable protecting systems are discussed, and the general mechanistic considerations for the deprotection process are described.Keywords
This publication has 92 references indexed in Scilit:
- Mild, orthogonal solid‐phase peptide synthesis: use of Nα‐dithiasuccinoyl (Dts) amino acids and N‐(iso‐propyldithio)carbonylproline, together with p‐alkoxybenzyl ester anchoring linkages*International Journal of Peptide and Protein Research, 1987
- 2‐(Pyridyl)ethyl Esters as Secure yet Readily Removable Polarophilic Carboxy‐Protection in Peptide SynthesisAngewandte Chemie International Edition in English, 1984
- PHOTOLABILE MULTI‐DETACHABLE p‐ALKOXYBENZYL ALCOHOL RESIN SUPPORTS FOR PEPTIDE FRAGMENT OR SEMI‐SYNTHESISInternational Journal of Peptide and Protein Research, 1980
- Sequential polypeptides. Part VII. The synthesis of poly-(L-glutaminyl-L-alanine), a model of the silks produced by sawflies of the family ArgidaeJournal of the Chemical Society, Perkin Transactions 1, 1972
- Application of the Principle of Hard and Soft Acids and Bases to Organic ChemistryJournal of the American Chemical Society, 1967
- 326. Hydrogen bonding in pyrocatechol monoesters and related compoundsJournal of the Chemical Society, 1963
- Alkylation and Cleavage of Methionine PeptidesJournal of the American Chemical Society, 1962
- The Removal of N-o-Nitrophenoxyacetyl and N-Chloroacetyl Groups from Peptides1Journal of the American Chemical Society, 1952
- Studies on Polypeptides. III.1 Novel Routes to α-Amino Acid and Polypeptide HydrazidesJournal of the American Chemical Society, 1952
- Amino Acid Derivatives. I. Carboallyloxy Derivatives of α-Amino Acids1,2Journal of the American Chemical Society, 1950