The sequences of an expressed rat α-tubulin gene and a pseudogene with an inserted repetitive element
- 1 November 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 300 (5890) , 330-335
- https://doi.org/10.1038/300330a0
Abstract
The rat genome contains two segments closely related to a rat α-tubulin mRNA. Both have been cloned and complete nucleotide sequences are presented. Analysis of the structure and sequence of one of these establishes it as a functional α-tubulin gene. The second segment is a processed α-tubulin pseudogene. Comparison of this pseudogene to the mRNA and gene coding for α-tubulin strongly suggests that a mature mRNA was involved in its origin. Features of the pseudogene and a dispersed repetitive element inserted within it possibly reflect a common RNA-mediated process of insertion.Keywords
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