Influence of 1,3-Butanediol on Tissue Lipids of Cold-exposed Rats

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Abstract
The influence of feeding the polyhydric alcohol 1,3-butanediol (BD), on tissue lipids of normal and cold-exposed rats was investigated. The addition of 20% BD to a 30% fat diet lowered adipose tissue lipids with a concomitant elevation of liver lipids at either normal or cold environments. Feeding a 30% fat diet to rats for 2 weeks and then exposing them to moderate cold of 5°, or severe cold -10° without food for 72 hours produced decreases in the total lipid content of epididymal adipose tissue, liver, and muscle. Rats fed a similar diet, without cold exposure but also starved for 72 hours, showed no decrease in the total quantity of adipose tissue lipids.