Adenocarcinoma of the Lung in Non-Hodgkin's Lymphoma

Abstract
The development of a 2nd neoplasm is a rare complication in patients with various types of primary malignancy. This report describes 2 patients with non-Hodgkin''s lymphoma who developed adenocarcinoma of the lung and malignant pleural effusion following many years of cytotoxic therapy. The value of cytological examination of the sputum and pleural aspirate, as well as fiberoptic bronchial biopsy in the diagnosis are emphasized. The higher incidence of this complication in patients with lymphocytic type of non-Hodgkin''s lymphoma may be due to their longer survival and probable basic immune defects which become overt after chemotherapy.

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