INFLUENCE OF ANTIPYRINE ON RESPIRATION, GLYCOLYSIS AND CHOLINESTERASE ACTIVITY IN RAT BRAIN

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Abstract
Antipyrine when added to the medium in which slices of rat cerebral cortex were suspended, had no effect on the rate of O2 consumption at 37.5[degree]C in concns. below 2 x 10-3 [image] At higher concns. than this, slight depression of respiration occurred. Anaerobic glycolysis in brain slices and cholinesterase activity in brain homogenates were depressed by concns. of antipyrine above 1 x 10-3 [image]. These conens. lie in the range in which activation of the heat defense mechanism might be expected if the drug is uniformly distributed in the animal on intraven. admn. Thus it appears that activation of the heat defense mechanism can occur without change in cortical O2 consumption and in the presence of conens. of antipyrine which may cause moderate depression of anaerobic glycolysis.