CHOLINESTERASE ACTIVITY IN NORMAL AND FEBRILE RABBIT BRAIN

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Abstract
Whole homogenates from normal and febrile rabbit brains hydrolyze respectively an avg. (12 detns.) of 9.07 and 8.81 mg. of acetylcholine/100 mg. of fresh tissue/hour. The difference between these means is not significant. The supernatent fractions of similar homogenates hydrolyze respectively an avg. (12 detns.) of 3.52 and 3.51 mg. of acetylcholine/100 mg. fresh tissue/hour. These means also are not significantly different. To the extent that these assays on whole brain can cast light upon processes mediating temp. regulation, they suggest that quantitative changes in cholinesterase assay are not associated with the "thermostatic reset" which occurs in fever.