PRESENT VIEWS ON THE MODE OF ACTION OF ACETYLCHOLINE IN THE CENTRAL NERVOUS SYSTEM

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Abstract
The author examines the theory, still imperfectly established, that acetylcholine is the central transmitter substance. The evidence, all obtained by the same methods that have elucidated peripheral nerve effects, is grouped under the following heads: 1. Central actions of acetylcholine applied superficially, intraventricularly, and intravascularly. 2. Central actions of eserine and of prostigmine. 3. Effects of atropine on the central actions of acetylcholine and eserine prostigmine. 4. Acetylcholine content of the tissue of the central nervous system. 5. Synthesis of acetylcholine. 6. Release of acetylcholine. 7. Enzymatic hydrolysis of acetylcholine. 8. Changes in the acetylcholine metabolism during some conditions of increased and decreased central activity. 9. Propagation of nerve impulses and release of acetylcholine from cholinergic nerve fibers.