THE GENES-CODING FOR A-ALPHA-CHAINS, B-BETA-CHAINS, AND GAMMA-CHAINS OF FIBRINOGEN MAP TO 4Q2
- 1 January 1984
- journal article
- research article
- Vol. 36 (4) , 760-768
Abstract
Cloned c[complementary]DNA probes for the A.alpha.-, B.beta.- and .gamma.-chains of human fibrinogen and Southern blotting techniques .gamma. to analyze DNA from a series of rodent .times. human somatic cell hybrids for the presence of specific fibrinogen-related sequences. The results provide evidence for the assignment of the 3 genes for fibrinogen to chromosome 4. By direct gene-dosage determination in 2 patients with chromosome 4 unbalanced rearrangements, the regional chromosomal assignment to 4q2 was refined, thus suggesting that these 3 genes whose expression is coordinately regulated are closely linked.This publication has 23 references indexed in Scilit:
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