Proteolytic Activity of Cu(II) Complex of 1-Oxa-4,7,10-triazacyclododecane
- 9 January 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (3) , 481-484
- https://doi.org/10.1021/ol702860h
Abstract
Proteolytic activity of the Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane (oxacyclen) was compared with that of the Cu(II) complex of 1,4,7,10-tetraazacyclododecane by using albumin, γ-globulin, and myoglobin as substrates. Values of kcat/Km were greater for Cu(II)oxacyclen by 40−80 times. The enhanced activity is attributed to the increased Lewis acidity of Cu(II) due to substitution of one nitrogen donor atom with oxygen.Keywords
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