Inhibition of Chemical Mediator Release from Human Leukocytes and Lung in Vitro by A Novel Antiallergic Agent, Kb-2413
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Immunopharmacology and Immunotoxicology
- Vol. 9 (4) , 511-521
- https://doi.org/10.3109/08923978709035229
Abstract
The effect of KB-2413 on IgE-mediated histamine and LTC4, release from leukocytes obtained from asthmatic patients who were sensitive to mites, and from human lung tissues passively sensitized with IgE myeloma serum was studied. KB-2413 inhibited the IgE-mediated chemical mediator release concentration dependently at a range of 10-4 to 3±10-3 M. KB-2413 did not enhance histamine release at a higher concentration unlike ketotifen. These findings suggest that the inhibitory effect of KB-2413 on the release of chemical mediators contributes to the anti-allergic activity of this compound.This publication has 8 references indexed in Scilit:
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