Pseudohypoparathyroidism: assays of parathyroid hormone and thyrocalcitonin.

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Abstract
Parathyroid hormone was measured by radioimmunoassay in thyroid venous plasma obtained from 2 patients with pseudohypoparathyroidism. An extract of a parathyroid gland from one patient produced a significant rise in the plasma Ca level of thyroparathyroidectomized rats. These results show that the parathyroid glands in pseudohypoparathyroidism can synthesize and secrete a substance which has the structural requirements for the immunological and biological activities of parathyroid hormone. The thyroid gland of one patient contained at least 50 times more thyrocalcitonin than normal human thyroid glands.