Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 1. Hydrazines
- 1 November 1986
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 29 (11) , 2273-2280
- https://doi.org/10.1021/jm00161a024
Abstract
The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described. The combination of preferred aromatic substituents in the 2-position coupled with alkyl substitution on the hydrazine moiety led to a number of potent compounds lacking sedation, ataxia, or lethality. 5-(2-Biphenylyl)-2-(1-methylhydrazino)-1,3,4-thiadiazole (4m) represents a new class of anticonvulsant agent and compares favorably with the standard drugs phenytoin, phenobarbital, and carbamezapine.This publication has 5 references indexed in Scilit:
- The relationship between plasma concentration of valproic acid and its anticonvulsant and behavioural effects in the ratNeuropharmacology, 1982
- Relationships Between Plasma Concentrations of Diphenylhydantoin, Phenobarbital, Carbamazepine, and 3‐Sulfamoylmethyl‐1,2‐Benzisoxazole (AD‐810), a New Anticonvulsant Agent, and Their Anticonvulsant or Neurotoxic Effects in Experimental AnimalsEpilepsia, 1979
- HYPOTENSIVE ACTIONS OF DRUGS ON UNANESTHETIZED NORMOTENSIVE AND METACORTICOID HYPERTENSIVE RATS DETERMINED BY A DIRECT RECORDING TECHNIQUE1965
- ANTICONVULSANT ACTIVITY OF SOME CARBINYLUREAS1962
- Routine Direct Measurement of Arterial Pressure in Unanesthetized RatsExperimental Biology and Medicine, 1960