CHARACTERIZATION OF SUPPRESSIVE IMMUNOGLOBULIN-BINDING FACTOR (IBF) .1. PRODUCTION OF IBF BY A THETA-POSITIVE LYMPHOMA (L-5178-Y)
- 1 January 1977
- journal article
- research article
- Vol. 119 (4) , 1266-1268
Abstract
L-5178-Y, a .theta.-positive, Fc receptor-bearing mouse thymona cell line spontaneously releases IBF upon short-term incubation in vitro. IBF produced by L-5178-Y cells is identical in its biologic activity with IBF produced by Fc receptor positive alloantigen-activated T [thymus-derived] cells. It suppresses the in vitro plaque reponse of mouse spleen cells to sheep erythrocytes by interfering mainly with the late phase of the generation of antibody-forming cells. L-5178-Y thymoma affords a homogeneous source of IBF in sufficient quantities for the study of its biochemical nature and the mechanism by which it iterferes with cells participating in antibody synthesis.This publication has 3 references indexed in Scilit:
- Spontaneous release of Fc receptor‐like material from human lymphoblastoid cell linesEuropean Journal of Immunology, 1977
- Inhibition of the in vitro 19S and 7S antibody response by immunoglobulin-binding factor (IBF) from alloantigen-activated T cellsCellular Immunology, 1976
- A Method of Increased Sensitivity for detecting Single Antibody-forming CellsNature, 1965