ELISA IN THE DIAGNOSIS OF WUCHERERIA-BANCROFTI INFECTION IN MAN - A TECHNIQUE FOR REDUCING CROSS-REACTIVITY

1 January 1980

journal article
research article

Vol. 58 (4) , 655-657

Abstract

The cross-reactivity of filarial heteroantigens, the non-availability of adult W. bancrofti for antigen extraction and the lack of structural information on purified filarial heteroantigens make the serological diagnosis of W. bancrofti infection in man a difficult problem. The use of immune sera from cattle infected with Setaria digitata when carrying out the enzyme-linked immunosorbent assay largely eliminated the cross-reactions with serum antibodies generally seen in subjects showing no evidence of W. bancrofti injection.

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1980
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Immunological diagnosis of human filariases: present possibilities, difficulties and limitations.
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