ANTIGENS OF SETARIA-DIGITATA - CROSS-REACTION WITH SURFACE-ANTIGENS OF WUCHERERIA-BANCROFTI MICROFILARIAE AND SERUM ANTIBODIES OF WUCHERERIA-BANCROFTI-INFECTED SUBJECTS

1 January 1980

journal article
research article

Vol. 58 (4) , 649-654

Abstract

Extracts of S. digitata were fractionated by DEAE-Sephadex A50 chromatography and the fractions obtained were used in the inhibition of indirect immunofluorescence of W. bancrofti microfilariae. The fractions were also tested by an enzyme-linked immunosorbent assay (ELISA) technique for reactivity against antibodies in the serum of patients with W. bancrofti infections. S. digitata contains several antigenic fractions that show cross-reactivity against filariasis sera; 2 of these fractions cross-reacted with surface antigens of W. bancrofti microfilariae but, when tested by the ELISA technique, these antigens did not show the highest reactivity against serum antibodies.

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