Effect of Gamma and Proton Irradiation on Lactic Dehydrogenase Isoenzymes

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Abstract
Exposure of monkeys to ionizing radiation causes marked alterations in the serum and the tissue LDH (Lactic dehydrogenase, M-LDH and H-LDH represent different types of molecules) enzyme activity. The increase of serum activity is a reflection of an immediate increase in the M-LDH isoenzymes, and subsequently an inversion and "crossover point" are observed. At this point the H-LDH isoenzyme activity predominates. The extent of the increase, the rate of the increase, and the extent of alteration of the isoenzyme ratios are functions of dose, energy level, and type of radiation. Gamma radiation produces the most rapid and severest response.