Characterization of skeletal phenotypes of TRα1PV and TRβPV mutant mice: implications for tissue thyroid status and T3 target gene expression
Open Access
- 1 January 2006
- journal article
- Published by SAGE Publications in Nuclear Receptor Signaling
- Vol. 4 (1) , e011
- https://doi.org/10.1621/nrs.04011
Abstract
Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation PV targeted to either the thyroid hormone receptor (TR) α1 or β gene. This perspective summarizes our findings to date and explores the wider implications for thyroid status and T3 target gene expression in individual tissues.Keywords
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