STUDIES ON PRODUCTION AND ACTION OF POLYMORPH MIGRATION STIMULATOR

  • 1 January 1976
    • journal article
    • research article
    • Vol. 24  (3) , 527-533
Abstract
Human blood monocytes are known to react with hydrocortisone in vitro to produce a factor which stimualtes polymorph migration. This study shows that the polymorph migration stimulator (PMS) is generated only by steroids with glucocorticoid activity. The interaction between steroid and monocytes is dependent on protein synthesis. Serum is necessary for the expression of the activity of the factor, but the steroid-monocyte reaction can occur in the absence of serum. The stimulatory effect on migration appears to be specific for polymorphs and does not affect mononuclear leukocytes. Spleen and bone marrow cells also react with corticosteroids to produce the polymorph migration stimulator.