Familial Hypohaptoglobinemia

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Abstract
1) A family is presented with an inherited deficiency of glucose-6-phosphate dehydrogenase and serum haptoglobin. 2) The inheritance patterns observed are consistent with those postulated for two genetically determined, independently segregating traits. 3) The presence of a benign metabolic defect, familial hypohaptoglobinemia, in individuals with Hp 2-1 and Hp 2-2 phenotypes and the lack of involvement to date of Hp 1-1 phenotypes is consistent with the hypothesis that some modification of the Hp2 allele is responsible for the low levels of haptoglobin observed. 4) The term hypohaptogiobinemia, rather than anhaptoglobinemia, is suggested for individuals who manifest a genetically determined depression in the level of circulating haptoglobin.