Inhibition of HLA‐DR antigen expression and of the allogeneic mixed leukocyte reaction by photochemical treatment

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Abstract
Treatment of human peripheral blood mononuclear cells with UVB light, the photosensitizing system 8‐methoxypsoralen plus UVA light (PUVA), or hematopor‐phyrin derivative plus visible light leads to an inhibition of their stimulatory capacity in an allogeneic mixed leukocyte reaction despite unaltered expression of HLA‐DR antigens when tested immediately after irradiation. However, HLA‐DR positive cells disappear among mononuclear cells in the interval between 4 and 8 h after treatment with either UVB, PUVA, hematoporphyrin derivative and light, or heating to 45°C. The expression of HLA‐DQ, but not HLA‐A,B,C, antigens, was similarly affected by these treatments. The significance of these results is discussed.

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