CONSTITUTIVE EXPRESSION OF PLATELET GLYCOPROTEINS BY THE HUMAN-LEUKEMIA CELL-LINE K562

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 60  (3) , 785-789
Abstract
The human leukemia cell line K562 was derived from a patient with chronic granulocytic leukemia. This cell line possesses phenotypic markers typical of erythroid and myeloid cells. Using a rabbit antiserum directed against purified platelet glycoproteins (PGP), evidence for the constitutive expression of PGP on the surface on K562 cells was obtained. PGP expressed were tentatively identified as Ila and Ill based on their apparent migration in a 7% sodium dodecyl-sulfate polyacrylamide gel. K562 may become an important tool for the study of early events involved in megakaryocytic differentiation.