The transient effect of strict glycaemic control on B cell function in newly diagnosed Type 1 (insulin-dependent) diabetic patients

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Abstract
Within 24h of diagnosis, 15 consecutive Type 1 (insulin-dependent) diabetic patients were allocated at random to one of two treatment groups: group A (n=9, mean age: 28 years, range: 17–35 years) was treated conventionally with one or two daily doses of insulin; group B (n=6, mean age: 27 years, range: 21–37 years) was treated with nine daily injections of fast-acting insulin for ten days and thereafter conventionally as for group A. The mean diurnal blood glucose concentration during the initial ten days of insulin treatment was 11.7±0.5mmol/l (mean±SEM) in group A and 6.4±0.3 mmol/l in group B (ppp<0.05). This study indicates that strict initial glycaemic control may lead to an earlier improvement in B cell function, but that this improvement is of short duration.