ALKALINE PHOSPHATASES IN VARIOUS TISSUES OF THE RAT DURING THE ALARM-REACTION

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Abstract
Alkaline phosphatase distribution and concn. were studied in normal rats and in rats exposed to alarming stimuli (formalin, cold and anoxia). When using glycerophosphate and fructose diphosphate as substrates, a marked increase in the phosphatase activity could be detected in the liver, lung, spleen, lymph nodes and thymus. No such increase was observed in these organs with yeast nucleic acid substrate. In the kidney, no difference was noted between the alkaline phosphatase of the control and of the exptl. animals, whatever substrate was employed. The rise in the activity of the liver and lymphatic tissue alkaline phosphatase appears to parallel the increased metabolism of these tissues during exposure to stress. Likewise, as there is a similar parallelism between the increased intensity tissue phosphatases and endocrine activity, the observations presented here seem to indicate a close relationship between this enzyme and corticoid secretion during the alarm-reaction.