Molecular characterization of ataxia telangiectasia T cell clones
- 1 April 1988
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 78 (4) , 316-319
- https://doi.org/10.1007/bf00291726
Abstract
We compared inversions of chromosome 14 in an ataxia telangiectasia clone and in a malignant T cell line (SUPT1). The R-banding chromosome analysis showed a clear difference between the distal breakpoint of the two inversions. Fine mapping of the distal breakpoint in the ataxia telangiectasia inv(14) was performed by in situ hybridization. We conclude that this breakpoint is centromeric to the immunoglobulin heavy chain locus and to the D14S1 anonymous locus. Our results favor the existence of an unknown oncogene in band 14q32.1.This publication has 39 references indexed in Scilit:
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