Metabolism of Etidocaine in Man

Publisher Website
Google Scholar
Abstract
Etidocaine [a new long-acting local anesthetic agent] and 8 metabolites excreted in urine of man were detected by GLC and investigated by GLC-mass spectrometry. Five metabolites were identified by comparison with authentic compounds as 2-amino-2''-butyroxylidide, 2-N-ethylamino-2''-butyroxylidide, 2-N-propylamino-2''-butyroxylidide, 2,6-dimethylaniline and 4-hydroxy-2,6-dimethylaniline. The structure of 1 of the remaining 3 metabolites is proposed to be 2-methyl-N3-(2,6-dimethylphenyl)-5-ethyl-4-imidazolidinone. The amounts of etidocaine and 7 of its metabolites excreted in a 48 h urine following epidural administration to a patient were estimated. Approximately 31% of the dose was accounted for.