THE RACIAL FACTOR IN THE PIGEON CROP-SAC METHOD OF BIOASSAY OF PROLACTIN

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Abstract
Different races and strains of doves and pigeons differed markedly in the response (increased wt.) of their crop-sacs to prolactin when this hormone was injected either intramusc. or subcutan. When the crop-sac responses obtained were expressed in terms of prolactin units an extreme variation of 5-fold was found among 6 races of pigeons and of 8-fold among 14 strains of doves. These variations were still more extreme when high dosage of prolactin was employed. When any race of pigeons was used for quantitative assay of prolactin by the wt. method it was first necessary to determine the useful range over which crop-sac wt. increased with dosage, and thereafter to establish a racial correction factor with the aid of a standard prolactin prep. The question of the source of differences in response of races was discussed.

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