DYSMYELOPOIETIC SYNDROME - SEQUENTIAL CLINICAL AND CYTOGENETIC STUDIES

  • 1 January 1980
    • journal article
    • research article
    • Vol. 55  (4) , 636-644
Abstract
Clinical and cytogenetic studies were done on 8 patients with dysmyelopoietic syndrome; 6 of these patients had refractory anemia with an excess of blasts (RAEB) and 2 patients had chronic myelomonocytic leukemia (CMML). The ages of these 8 patients (3 female and 5 male) ranged from 56-70 yr (median 61.5 yr). Seven of the 8 patients died 3-86 mo. (median, 11 mo.) after the onset of symptoms of hemorrhage or infections. Cytogenetic studies of bone marrow cells with the Q[quinacrine]-banding technique showed clonal karyotypic abnormalities in 7 of the 8 patients (87.5%). Five of the 7 chromosomally abnormal patients had very complex karyotypes; all 7 patients had at least 1 of 4 specific changes: -5 (or 5q-), -7, +8 and +21. Three of the 7 patients with abnormal karyotypes had had some exposure to potential mutagenic/carcinogenic agents. Five of the 7 patients had serial cytogenetic analyses, 4 of which showed evolution of the karyotype to further complexity; in 2 cases, this coincided with the evolution of the disease into acute leukemia. The median survival time of patients whose initial cytogenetic samples showed normal and abnormal metaphases was more than twice that of patients who had only abnormal metaphases initially (12 mo. vs. 4.5 mo.).