Efflux of Cyclic Nucleotides from Rat Pineal: Release of Guanosine 3′,5′-Monophosphate from Sympathetic Nerve Endings
- 8 July 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 197 (4299) , 174-176
- https://doi.org/10.1126/science.195336
Abstract
Potassium and norepinephrine stimulate the efflux of adenosine 3',5'-monophosphate (cyclic AMP) and guanosine 3',5'-monophosphate (cyclic GMP) from intact pineal glands. The postsynaptic beta-adrenergic receptor mediates the efflux of cyclic AMP. In contrast, the efflux of cyclic GMP requires calcium and intact nerve endings. It appears that sympathetic nerve endings may release cyclic GMP into the synaptic space.Keywords
This publication has 19 references indexed in Scilit:
- Hormone-Induced Cyclic Guanosine Monophosphate Secretion from Guinea Pig Pancreatic LobulesScience, 1977
- Release of cerebral cyclic AMP into push-pull perfusates in freely moving ratsBrain Research, 1976
- Characterization of the Metabolism of Exogenous Cyclic AMP by Perfused Rat Heart and Incubated Prepubertal Rat OvaryActa Physiologica Scandinavica, 1975
- Cytochemical localization of cyclic nucleotide phosphodiesterase activity at developing synapsesBrain Research, 1974
- The Pineal Gland: A Neurochemical TransducerScience, 1974
- Cyclic 3′,5′-Nucleotide Phosphodiesterase: Cytochemical Localization in Cerebral CortexScience, 1971
- The metabolism of exogenous cyclic AMP at low concentrations by thymic lymphocytesBiochemical and Biophysical Research Communications, 1971
- The effect of oxotremorine and atropine on cGMP and cAMP levels in mouse cerebral cortex and cerebellumBiochemical and Biophysical Research Communications, 1970
- Melatonin Synthesis: Adenosine 3′,5′-Monophosphate and Norepinephrine Stimulate N -AcetyltransferaseScience, 1970
- CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE IN BRAINJournal of Histochemistry & Cytochemistry, 1969