Molecular Mechanisms of Erythropoietin Signaling
- 16 March 2001
- journal article
- Published by S. Karger AG in Nephron
- Vol. 87 (3) , 215-222
- https://doi.org/10.1159/000045918
Abstract
Erythropoietin is an obligatory growth factor for red blood cell production. The receptor for erythropoietin contains a single membrane-spanning domain with no intrinsic tyrosine kinase motifs. On binding to erythropoietin, the receptor dimerizes and activates multiple intracellular signaling molecules, including but not limited to JAK2, STAT5, PI 3-kinase, IRS-2, RAS, and Ca2+ channels. This review focuses on cytoplasmic signaling cascades involved in erythropoietin action.Keywords
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